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Description

AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB₁. It is used in scientific research for mapping the distribution of CB₁ receptors

AM-694 is an agonist for cannabinoid receptors. Affinities are: with a K_i of 0.08 nM at CB₁ and 18x selectivity over CB₂ with a K_i of 1.44 nM.^[1] It is unclear what is responsible for this unusually high CB₁ binding affinity, but it makes the ¹⁸F radiolabelled derivative of AM-694 useful for mapping the distribution of CB₁ receptors in the body.

AM-694

• Molecular FormulaC₂₀H₁₉FINO
• Average mass435.274 Da
• Monoisotopic mass435.049530 Da
• ChemSpider ID8064843
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