5F-ADB powder online is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug. 5F-ADB is a potent agonist of the CB1 receptor,though it is unclear whether it is selective for this target. 5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance.
5F-ADB is an indazole synthetic cannabinoid receptor agonist that has greater potency than Δ9-THC and earlier generation synthetic cannabinoids . The first human use reports involving 5F-ADB appeared in 2014. Common methods of use include smoking and vaping . In laboratory-confirmed cases of use, symptoms associated with 5F-ADB include confusion, agitation, psychosis, altered consciousness, headache, dizziness, mydriasis, and vomiting . On the basis of multiple analytically confirmed fatalities, 5F-ADB is regarded as one of the most dangerous synthetic cannabinoids.
Adverse Reactions in Humans
The acute effects of THC (and consequently cannabis) include: relaxation, euphoria,lethargy, depersonalisation, distorted perception of time, impaired motor performance,hallucinations, paranoia, confusion, fear, anxiety, dry mouth, conjunctival injection (“redeyes”), tachycardia, and nausea and vomiting. Similar effects to cannabis have been reported for SCRAs such as 5F-ADB. Compared to cannabis, severe and fatal poisoning appears to be more common with SCRAs. 14 Poisoning may include rapid loss of consciousness/coma, cardiovascular effects (such as hypertension, tachycardia,bradycardia, chest pain, myocardial infarction, and stroke), seizures and convulsions,
vomiting/hyperemesis, delirium, agitation, psychosis, and aggressive and violent behaviour.